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KMID : 0358819790060010007
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1979 Volume.6 No. 1 p.7 ~ p.14
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Tissue Reaction to Implanted Dimethylpolysiloxanes and the Role of Steroids (Experimental Study)
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Huh Eun
Ham Ki-Sun
Kim Sun-Mu
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Abstract
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Silicone has been used in clinical plastic surgery for many years by its characteristic properties of chemical inertness, high water repellancy, low volatility, resistancy to decomposition by heat and low surface tension. Inspite of its biological inertness, we still experienced the tissue reactions on using the various types of the silicones, and many attempts were carried out to reduce the tissue reactions. We observed the tissued reactions on the 2 types of the silicones in rats, silicone blocks and fluids, and the effects of local and systemic application of the steroids on them.
The results are as follows:
1. Tissue reactions around the silicones appeared even 3 days after insertion.
Initially, acute inflammatory cellular reponses were found on the surrounding tissues.
It became less cellular day by day and fibrotic changes were noted in later.
2. The tissue reactions around the injected silicone fluids revealed more acute inflammatory response than that around silicone blocks.
3. The effects of local triamcinolone instillation around the silicone blocks were considered has having no significant effect on the capsule formation but mild delay was noted in the cellular response around them compared with silicone blocks.
4. The effects of systemic injection of triamcinolone acetate were more aggravated the acute inflammatory responses.
5. The injected silicone fluids have a tendency to disperse each other and injected silicone fluids were disappeared from the injected sites about 25% of the cases, perhaps by phagocytosis or migration.
6. The systemic applications of the triamcinolone acetate lead to the rat’s death almost within 3wks. The lung and kidney from expired rats showed congestive changes.
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